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Capsugel Vcaps® Plus capsules provide an ideal solution for immediate release pharmaceutical products, exclusively using HPMC without gelling agents. These capsules deliver excellent dissolution profiles with consistent performance across different pH levels. Notably, they maintain low moisture content, ensuring product stability. Capsugel Vcaps® Plus capsules are also easy to work with during production due to their great machinability and offer a visually appealing final product.
Polymer science and engineering have opened up new possibilities for designing capsules tailored to specific APIs. Capsugel Vcaps® Plus capsules are a noteworthy addition to this field. They dissolve quickly and predictably at various pH levels, regardless of cations or food components, they perform like gelatin.
In addition, they also offer extra benefits, especially a lower moisture content, making them suitable for moisture-sensitive drugs and manufacturing processes. Because of their low sensitivity to moisture, you have various storage options with a reduced risk of brittleness or breakage.
HPMC capsules are known for their resilience and inertness, remaining unaffected by cross-linking or extreme storage conditions. Sourced from renewable plants and endorsed by the global regulatory community, Capsugel Vcaps® Plus capsules closely resemble the appearance and performance of gelatin, providing scientists worldwide with valuable new options.
Capsugel Vcaps® Plus capsules have gained approval from the Vegetarian Society, earned verification from the non-GMO Project, and proudly hold Kosher and Halal certifications, effectively meeting essential criteria for both patients and consumers. This accreditation stems from the meticulous adherence to the International Pharmaceutical Excipient Council's (IPEC) Good Manufacturing Practice (GMP) Guide for Bulk Pharmaceutical Excipients during the manufacturing process. These capsules are produced within ISO 9001 certified facilities. Their appearance, akin to traditional gelatin capsules with a sleek and shiny surface, further reinforces the widespread perception that capsules are effortless to swallow (1).
*Please note: Empty, transparent, and colored capsules without carmine are vegan certified. Imprinted capsules must use shellac-free ink for vegan certification. Capsules with carmine are not vegan certified.
Capsugel Vcaps® Plus capsules exhibit superior characteristics compared to first-generation HPMC capsules. They showcase reduced weight variations and boast a weight-range profile that closely resembles that of traditional gelatin capsules. Detailed electron micrographs of Capsugel Vcaps® Plus capsules reveal a consistently smooth and even surface, indicating a higher level of manufacturing quality.
Extensive testing has been conducted on various high-speed capsule filling machines, and the results demonstrate outstanding performance, with rejection rates falling below 0.01%. In a recent assessment involving over 30 filling operations encompassing intermittent motion, continuous motion, and semi-automatic machines,Capsugel Vcaps® Plus capsules consistently achieved an impressive average yield rate of 99.86%. These results ranged from 99.782% to 100.0%, reaffirming their exceptional performance.
Secondary gelling agents and ionic gel promoters, which are employed in certain HPMC capsules, can potentially impede the release of active ingredients. In contrast, Capsugel Vcaps® Plus capsules utilize an exclusive manufacturing method that obviates the necessity for gelling systems. These capsules exhibit disintegration and content release that remains unaffected by both the pH levels and ionic strength of the test media.
